Back to Search Start Over

Behind the Scene: Surprises and Snags of Pseudogenes

Authors :
Mario J. Simirgiotis
Tanveer Majeed
Musarrat Abbas Khan
Hafiz Ishfaq Ahmad
M Mahnoor
Hebatallah A. Nasser
Abdul Jabbar
Shakeel Ahmed
Muhammad Imran
Mahmoud M. Tolba
Source :
Critical Reviews in Eukaryotic Gene Expression. 31:67-78
Publication Year :
2021
Publisher :
Begell House, 2021.

Abstract

The junk DNA "pseudogenes," known as genomic fossils, are characterized by their ubiquitousness and abundance within the genomic structure. These genomics sets are recognized by the potential activity of meta-regulating the parent genes; these are transcribed into interfering RNA, consequently acting on miRNA concentration, thereby shedding light on the crosstalk of the pseudogenes' miRNA, siRNA, lncRNA/tumor therapy co-relationship. Moreover, an upcoming visualization regarding pseudogenes is under investigation, which describes the potentiality of pseudogenes as a fundamental component of cancerous evolutionary processing tools. Accordingly, here is a systematic review covering pseudobirth, pseudosignatures, and functional properties of pseudogenes, concluding that these pseudogenes are hypothetically predictive tumor therapies.

Details

ISSN :
10454403
Volume :
31
Database :
OpenAIRE
Journal :
Critical Reviews in Eukaryotic Gene Expression
Accession number :
edsair.doi.dedup.....182cf31a3ce725f649447efba1bcd8c3