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The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice
- Source :
- Nature Protocols, Nature Protocols, 2009, 4 (10), pp.1560-4. ⟨10.1038/nprot.2009.125⟩, Nature Protocols, Nature Publishing Group, 2009, 4 (10), pp.1560-4. 〈10.1038/nprot.2009.125〉, Nature Protocols, Nature Publishing Group, 2009, 4 (10), pp.1560-4. ⟨10.1038/nprot.2009.125⟩, Scopus-Elsevier
- Publication Year :
- 2009
-
Abstract
- International audience; Long-term functional deficits after a brain injury are difficult to assess in the mouse. If no deficit is observed, researchers could conclude either that the animal has fully recovered or that the tests they used were not appropriate or sensitive enough to the modality of the deficits. We present here a detailed protocol describing how to conduct an adhesive removal test for this species. It consists of applying adhesive tape on each forepaw of the animal and measuring the time-to-contact and the time-to-remove them. This behavior implies correct paw and mouth sensitivity (time-to-contact) and correct dexterity (time-to-remove). To decrease interindividual differences, we recommend a training session (1 week, 1 trial per day) before surgical procedures so that mice to reach optimal performances.
- Subjects :
- 0303 health sciences
medicine.medical_specialty
Behavior, Animal
business.industry
[SCCO.NEUR]Cognitive science/Neuroscience
Surgical procedures
Neuropsychological Tests
General Biochemistry, Genetics and Molecular Biology
Functional Laterality
Brain Ischemia
03 medical and health sciences
Mice
0302 clinical medicine
Physical medicine and rehabilitation
[ SCCO.NEUR ] Cognitive science/Neuroscience
Medicine
Animals
Surgical Tape
business
Surgical tape
030217 neurology & neurosurgery
Psychomotor Performance
030304 developmental biology
Subjects
Details
- ISSN :
- 17502799
- Volume :
- 4
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Nature protocols
- Accession number :
- edsair.doi.dedup.....182841474d575ba15e2bbb5d834c0cff