Back to Search
Start Over
Alzheimer's amyloid-β peptide disturbs P2X7 receptor-mediated circadian oscillations of intracellular calcium
Alzheimer's amyloid-β peptide disturbs P2X7 receptor-mediated circadian oscillations of intracellular calcium
- Source :
- Folia Neuropathologica, Vol 54, Iss 4, Pp 360-368 (2016)
- Publication Year :
- 2017
-
Abstract
- Recent data indicate that Alzheimer's disease (AD) is associated with disturbances of the circadian rhythm in patients. We examined the effect of amyloid-β (Aβ) peptide, the main component of the senile plaques playing a critical role in the deregulation of calcium (Casup2+/sup) homeostasis in AD, on the circadian oscillation of cytosolic calcium (Casup2+/sup) levelsiiin vitro/i/i. The experiments we carried out in human primary skin fibroblasts. This cell line was previously shown to exhibit circadian rhythms of clock genes. Moreover, the basic clock properties of these peripheral cells closely mimic those measured physiologically and behaviorally in human and do not change during aging. In this study we showed that i) cytosolic Casup2+/suposcillations depend on the activation of purinergic P2X7 receptors; and ii) these oscillations are abolished in the presence of Aβ. In total, our new findings may help to deepen our understanding of the molecular mechanisms involved in AD-related circadian alterations.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Aging
Intracellular Space
lcsh:Medicine
chemistry.chemical_element
amyloid-β
Calcium
P2X7 receptors
Calcium in biology
Pathology and Forensic Medicine
03 medical and health sciences
Amyloid beta-Protein Precursor
0302 clinical medicine
Alzheimer Disease
Internal medicine
medicine
Humans
Circadian rhythm
Senile plaques
Neurons
lcsh:R
Purinergic receptor
Circadian Rhythm
CLOCK
Cytosol
030104 developmental biology
Endocrinology
chemistry
circadian rhythms
Neurology (clinical)
Receptors, Purinergic P2X7
Alzheimer’s disease
030217 neurology & neurosurgery
Homeostasis
Subjects
Details
- ISSN :
- 1509572X
- Volume :
- 54
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Folia neuropathologica
- Accession number :
- edsair.doi.dedup.....1805c265657d504b56406d88223c24ca