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Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation
- Source :
- J Pediatr Psychol
- Publication Year :
- 2015
-
Abstract
- Objective This study described the prospective relationship between pharmacological and behavioral measures of 6-mercaptopurine (6MP) medication adherence in a multisite cohort of pediatric patients diagnosed with cancer (N = 139). Methods Pharmacological measures (i.e., metabolite concentrations) assessed 6MP intake. Behavioral measures (e.g., electronic monitoring) described adherence patterns over time. Results Three metabolite profiles were identified across 15 months: one group demonstrated low levels of both metabolites (40.8%) consistent with nonadherence and/or suboptimal therapy; two other groups demonstrated metabolite clusters indicative of adequate adherence (59.2%). Those patients whose metabolite profile demonstrated low levels of both metabolites had consistently lower behavioral adherence rates. Conclusions To our knowledge, this was the first study to prospectively validate a pharmacological measure of medication adherence with a behavioral adherence measure in a relatively large sample of pediatric patients with cancer. Using multiple methods of adherence measurement could inform clinical care and target patients in need of intervention.
- Subjects :
- Adult
Male
medicine.medical_specialty
Antimetabolites, Antineoplastic
Adolescent
Metabolite
Medication adherence
Multiple methods
Medication Adherence
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Internal medicine
Developmental and Educational Psychology
medicine
Humans
030212 general & internal medicine
Prospective Studies
Clinical care
Child
business.industry
Mercaptopurine
Cancer
Reproducibility of Results
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Pediatric cancer
Large sample
chemistry
030220 oncology & carcinogenesis
Pediatrics, Perinatology and Child Health
Cohort
Physical therapy
Female
business
Regular Articles
Subjects
Details
- ISSN :
- 1465735X
- Volume :
- 42
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of pediatric psychology
- Accession number :
- edsair.doi.dedup.....180395f32189ec65770a50bd2b0fbe05