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Visual memory dysfunction as a neurocognitive endophenotype in bipolar disorder patients and their unaffected relatives. Evidence from a 5-year follow-up Valencia study

Authors :
Anabel Martínez-Arán
Esther Setién-Suero
Joan Vicent Sánchez-Ortí
Joan Vila-Francés
Inmaculada Fuentes-Durá
Rafael Tabarés-Seisdedos
Gabriel Selva-Vera
Juan Carlos Ruiz-Ruiz
Patricia Correa-Ghisays
Vicent Balanzá-Martínez
Rosa Ayesa-Arriola
Candela Conforte-Molina
Benedicto Crespo-Facorro
Constanza San-Martín
Juliana Vivas-Lalinde
Carlos Martínez-Pérez
Universidad de Cantabria
Source :
Journal of Affective Disorders Volume 257, 1 October 2019, Pages 31-37, UCrea Repositorio Abierto de la Universidad de Cantabria, Universidad de Cantabria (UC)
Publication Year :
2019

Abstract

BACKGROUND: Scarce research has focused on Visual Memory (VM) deficits as a possible neurocognitive endophenotype of bipolar disorder (BD). The main aim of this longitudinal, family study with healthy controls was to explore whether VM dysfunction represents a neurocognitive endophenotype of BD. METHODS: Assessment of VM by Rey-Osterrieth Complex Figure Test (ROCF) was carried out on a sample of 317 subjects, including 140 patients with BD, 60 unaffected first-degree relatives (BD-Rel), and 117 genetically-unrelated healthy controls (HC), on three occasions over a 5-year period (T1, T2, and T3). BD-Rel group scores were analyzed only at T1 and T2. RESULTS: Performance of BD patients was significantly worse than the HC group (p < 0.01). Performance of BD-Rel was also significantly different from HC scores at T1 (p < 0.01) and T2 (p?=?0.05), and showed an intermediate profile between the BD and HC groups. Only among BD patients, there were significant differences according to sex, with females performing worse than males (p?=?0.03). Regarding other variables, education represented significant differences only in average scores of BD-Rel group (p?=?0.01). LIMITATIONS: Important attrition in BD-Rel group over time was detected, which precluded analysis at T3. CONCLUSIONS: BD patients show significant deficits in VM that remain stable over time, even after controlling sociodemographic and clinical variables. Unaffected relatives also show stable deficits in VM. Accordingly, the deficit in VM could be considered a potential endophenotype of BD, which in turn may be useful as a predictor of the evolution of the disease. Further studies are needed to confirm these findings. VB-M is supported by the national grant PI16/01770 (PROBILIFE Study), from the ISCIII. RTS was supported in part by grant PROMETEOII/2015/021 from Generalitat Valenciana and the national grands PI14/00894, PI17/00719 and PIE14/00031 from ISCIII-FEDER. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Details

Language :
English
Database :
OpenAIRE
Journal :
Journal of Affective Disorders Volume 257, 1 October 2019, Pages 31-37, UCrea Repositorio Abierto de la Universidad de Cantabria, Universidad de Cantabria (UC)
Accession number :
edsair.doi.dedup.....17f5a34f796b93b8c2a3221c5738f2e8