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Soluble tumor necrosis factor receptors as surrogate markers for the assessment of zidovudine treatment in asymptomatic HIV-1 infection
- Source :
- Journal of acquired immune deficiency syndromes and human retrovirology, 10(5), 531-539. Lippincott Williams and Wilkins
- Publication Year :
- 1995
-
Abstract
- In untreated, asymptomatic human immunodeficiency virus type 1 (HIV-1) infection, elevated serum concentrations of soluble receptors for tumor necrosis factor (sTNFR) types I and II are associated with progression to AIDS. To assess the utility of sTNFRs as markers for the assessment of antiretroviral treatment, sTNFRs were sequentially determined in 47 asymptomatic HIV-1-infected men, who participated in a double-blind, randomized, placebo-controlled study. Progression to AIDS or severe AIDS-related complex occurred in six zidovudine (ZDV)- and six placebo-treated subjects. During ZDV treatment (n = 28) both types of sTNFRs declined compared with baseline and placebo, whereas they increased during placebo treatment (n = 19). A sustained decline of sTNFRs occurred only in subjects who experienced no disease progression. During the first 3 months of ZDV treatment, the hazard ratio for disease progression when sTNFR type II rose above the baseline value plus 5% was significantly increased (hazard ratio: approximately 25; 95% confidence interval: approximately 1.5-400; p < 0.03). Simultaneously determined CD4+ counts and serum neopterin levels showed a similar pattern in progressors and nonprogressors. Thus, in contrast to CD4+ counts and neopterin levels, sTNFR concentrations, especially those of the type II STNFR, appear to be valuable surrogate markers for monitoring the efficacy of ZDV treatment in asymptomatic HIV-1 infection.
- Subjects :
- medicine.medical_specialty
biology
business.industry
Immunology
Hazard ratio
AIDS-related complex
Neopterin
medicine.disease
biology.organism_classification
Placebo
Asymptomatic
Gastroenterology
Zidovudine
chemistry.chemical_compound
chemistry
Virology
Immunopathology
Internal medicine
medicine
Immunology and Allergy
medicine.symptom
business
Sida
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 10779450
- Volume :
- 10
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of acquired immune deficiency syndromes and human retrovirology
- Accession number :
- edsair.doi.dedup.....17f3b85a4125f022af16ff80ff99dda4