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Effects of Covalently Bound Silica-Nitroimidazole Drug Particles on Entamoeba histolytica
- Source :
- Journal of Infectious Diseases. 159:303-309
- Publication Year :
- 1989
- Publisher :
- Oxford University Press (OUP), 1989.
-
Abstract
- Most commonly used antiamoebic drugs are effective in invasive amebiasis, but their response against trophozoites of Entamoeba histolytica, present in the lumen of the human colon, is inadequate. We report the development of an antiamoebic drug carrier that may be effective against luminal infections. Our preparation consists of small silica particles (5-10 microns in diameter) covalently linked to a potent antiamoebic drug, 2-(4-aminophenoxymethyl)-5-nitro-1-methyl imidazole. Silica-drug particles were injected into mice, hamsters, and guinea pigs. We found that trophozoites phagocytosed the particles in vivo and in vitro, followed by rapid cell death due to the released drug. Analysis of mouse serum revealed that no drug was absorbed from the intestine after placement of the drug-containing particles in the intestine. The antiamoebic activity of particles recovered from the intestine was almost fully retained. This novel antiamoebic concept may be useful for luminal therapy for asymptomatic amebiasis and may minimize side effects and frequency of administration.
- Subjects :
- Drug
Colon
media_common.quotation_subject
Drug Evaluation, Preclinical
Lumen (anatomy)
Caviidae
Biology
Microbiology
chemistry.chemical_compound
Entamoeba histolytica
Species Specificity
In vivo
Cricetinae
Animals
Immunology and Allergy
Amebicides
media_common
Nitroimidazole
Silicon Dioxide
biology.organism_classification
In vitro
Infectious Diseases
chemistry
Nitroimidazoles
Drug carrier
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 159
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....17ef0a5199cad71cc48eea0ab53ae7c0