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Early life stress affects the miRNA cargo of epididymal extracellular vesicles in mouse
- Source :
- Biology of Reproduction. 105:593-602
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Sperm RNA can be modified by environmental factors and has been implicated in communicating signals about changes in a father's environment to the offspring. The small RNA composition of sperm could be changed during its final stage of maturation in the epididymis by extracellular vesicles (EVs) released by epididymal cells. We studied the effect of exposure to stress in early postnatal life on the transcriptome of epididymal EVs using a mouse model of transgenerational transmission. We found that the small RNA signature of epididymal EVs, particularly miRNAs, is altered in adult males exposed to postnatal stress. In some cases, these miRNA changes correlate with differences in the expression of their target genes in sperm and zygotes generated from that sperm. These results suggest that stressful experiences in early life can have persistent biological effects on the male reproductive tract that may in part be responsible for the transmission of the effects of exposure to the offspring.
- Subjects :
- Epididymis
Male
Small RNA
Zygote
Offspring
RNA
Cell Biology
General Medicine
Biology
Sperm
Cell biology
Mice, Inbred C57BL
Transcriptome
Disease Models, Animal
Extracellular Vesicles
Mice
MicroRNAs
medicine.anatomical_structure
Reproductive Medicine
Adverse Childhood Experiences
microRNA
medicine
Animals
Humans
Subjects
Details
- ISSN :
- 15297268 and 00063363
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Biology of Reproduction
- Accession number :
- edsair.doi.dedup.....17e9cce45c5924f791cd6e3b5d472d54