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Optimization of 2-aminothiazole derivatives as CCR4 antagonists
- Source :
- Bioorganicmedicinal chemistry letters. 16(10)
- Publication Year :
- 2005
-
Abstract
- A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [ 125 I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.
- Subjects :
- Receptors, CCR4
Chemistry
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Antagonist
Pharmaceutical Science
Biochemistry
Chemical synthesis
Combinatorial chemistry
Bioavailability
Cell Line
Thiazoles
Pharmacokinetics
Oral administration
Drug Discovery
Molecular Medicine
Potency
Humans
Receptors, Chemokine
Receptor
Molecular Biology
G protein-coupled receptor
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....17df206e52dced047c17c3bb241d50bc