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Primary antibody deficiency and Crohn's disease
- Source :
- Postgraduate Medical Journal. 75:161-164
- Publication Year :
- 1999
- Publisher :
- Oxford University Press (OUP), 1999.
-
Abstract
- Summary Five patients with primary antibody deficiency were investigated because of intermittent but persistent diarrhoea of several years duration despite immunoglobulin replacement therapy. We found no evidence of Giardia lambia or other intestinal pathogens to explain their gastrointestinal symptoms. All five had definite radiological evidence of small bowel Crohn's disease and three had histological specimens available with abnormalities consistent with Crohn's disease. One patient had a non-caseating granuloma in an oral ulcer. A second patient with stricturing disease in the small bowel had a mucosal inflammatory infiltrate with non-caseating granulomas. A third had transmural inflammation but no granulomas. All five patents were diagnosed as having Crohn's disease and have responded symptomatically to steroid therapy.
- Subjects :
- Adult
Diarrhea
Male
medicine.medical_specialty
Pathology
Short Report
Disease
Gastroenterology
Inflammatory bowel disease
Diagnosis, Differential
Crohn Disease
Internal medicine
medicine
Humans
Crohn's disease
biology
business.industry
Immunologic Deficiency Syndromes
General Medicine
Middle Aged
medicine.disease
digestive system diseases
Granuloma
Etiology
biology.protein
Female
Steroids
medicine.symptom
Differential diagnosis
Antibody
business
Subjects
Details
- ISSN :
- 14690756 and 00325473
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Postgraduate Medical Journal
- Accession number :
- edsair.doi.dedup.....17dbf6f8dc359d2385ae81bd06119044