Supplementary Figures 1 - 8 from A MicroRNA Cluster at 14q32 Drives Aggressive Lung Adenocarcinoma

PDF file - 1289KB, Fig S1- Box plots of the risk score values in the training and test set. Fig S2- SAM plot of 10 lung AC versus 10 matched nonmalignant lung samples. Fig S3- Pathway enrichment analysis based on predicted genes targeted by top 10 miRs discriminating lung AC vs. nonmalignant lung. Fig S4- Hierarchical clustering based on miR expression in 91 lung ACs, without including nonmalignant samples. Fig S5- Hierarchical clustering based on 306 most variable expressed miRs in 474 lung ACs from TCGA-Lung Adenocarcinoma cohort. Fig S6- Box plots of average expression of genes involved in Notch pathway, c-Myc targets, embryonic stem-cell signature among the 3 miR clusters in 51 lung AC. Fig S7- Kaplan-Meier plots of OS in the training set for 3 miRs encoded at the 14q32 region and selected for validation. Fig S8- Scatterplot matrix showing the correlation between 21 miRs encoded at 14q32.