Back to Search
Start Over
Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility
- Source :
- Pediatric research. 75(6)
- Publication Year :
- 2013
-
Abstract
- Evidence for an inherited genetic risk for pediatric acute lymphoblastic leukemia has been provided in several studies. Most of them focused on coding regions. However, those regions represent only 1.5% of the entire genome. In acute lymphoblastic leukemia (ALL), it has been suggested that the expression of microRNAs (miRNAs) is dysregulated, which suggests that they may have a role in ALL risk. Changes in miRNA function may occur through single-nucleotide polymorphisms (SNPs). Therefore, the aim of this study was to evaluate whether polymorphisms in pre-miRNAs, and/or miRNA-processing genes, contribute to a predisposition for childhood ALL. In this study, we analyzed 118 SNPs in pre-miRNAs and miRNA-processing genes in 213 B-cell ALL patients and 387 controls. We found 11 SNPs significantly associated with ALL susceptibility. These included three SNPs present in miRNA genes (miR-612, miR-499, and miR-449b) and eight SNPs present in six miRNA biogenesis pathway genes (TNRC6B, DROSHA, DGCR8, EIF2C1, CNOT1, and CNOT6). Among the 118 SNPs analyzed, rs12803915 in mir-612 and rs3746444 in mir-499 exhibited a more significant association, with a P value
- Subjects :
- Genetics
RNA, Untranslated
biology
DGCR8
Single-nucleotide polymorphism
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Non-coding RNA
Genome
Polymorphism, Single Nucleotide
MicroRNAs
Pediatrics, Perinatology and Child Health
microRNA
biology.protein
SNP
Humans
Genetic Predisposition to Disease
Child
Gene
Drosha
Genetic Association Studies
Subjects
Details
- ISSN :
- 15300447
- Volume :
- 75
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Pediatric research
- Accession number :
- edsair.doi.dedup.....17cf20a3dcbc27f385d09b196df9bf90