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Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 10, p e0258187 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Background Nasopharyngeal carcinoma (NPC) is a cancer of epithelial origin with a high incidence in certain populations. While NPC has a high remission rate with concomitant chemoradiation, recurrences are frequent, and the downstream morbidity of treatment is significant. Thus, it is imperative to find alternative therapies. Methods We employed a Search Tag Analyze Resource (STARGEO) platform to conduct a meta-analysis using the National Center for Biotechnology’s (NCBI) Gene Expression Omnibus (GEO) to define NPC pathogenesis. We identified 111 tumor samples and 43 healthy nasopharyngeal epithelium samples from NPC public patient data. We analyzed associated signatures in Ingenuity Pathway Analysis (IPA), restricting genes that showed statistical significance (p Results Our meta-analysis identified activation of lipopolysaccharide (LPS)-induced tissue injury in NPC tissue. Additionally, interleukin-1 (IL-1) and SB203580 were the top upstream regulators. Tumorigenesis-related genes such as homeobox A10 (HOXA10) and prostaglandin-endoperoxide synthase 2 (PTGS2 or COX-2) as well as those associated with extracellular matrix degradation, such as matrix metalloproteinases 1 and 3 (MMP-1, MMP-3) were also upregulated. Decreased expression of genes that encode proteins associated with maintaining healthy nasal respiratory epithelium structural integrity, including sentan-cilia apical structure protein (SNTN) and lactotransferrin (LTF) was documented. Importantly, we found that etanercept inhibits targets upregulated in NPC and LPS induction, such as MMP-1, PTGS2, and possibly MMP-3. Conclusions Our analysis illustrates that nasal epithelial barrier dysregulation and maladaptive immune responses are key components of NPC pathogenesis along with LPS-induced tissue damage.
- Subjects :
- Lipopolysaccharides
Carcinogenesis
Epidemiology
Cancer Treatment
Gene Expression
Matrix metalloproteinase
Pathogenesis
Mathematical and Statistical Techniques
Medicine and Health Sciences
Molecular Targeted Therapy
Immune Response
Nasopharyngeal Carcinoma
Multidisciplinary
Cancer Risk Factors
Statistics
Metaanalysis
Up-Regulation
Gene Expression Regulation, Neoplastic
Lactotransferrin
medicine.anatomical_structure
Oncology
Physical Sciences
Medicine
Research Article
Signal Transduction
Science
Immunology
Down-Regulation
Research and Analysis Methods
Signs and Symptoms
Immune system
Gene Types
Cell Line, Tumor
Genetics
medicine
Humans
Statistical Methods
Inflammation
business.industry
Carcinoma
Cancers and Neoplasms
Biology and Life Sciences
Cancer
medicine.disease
Epithelium
Nasopharyngeal carcinoma
Medical Risk Factors
Cancer research
Regulator Genes
Respiratory epithelium
Clinical Medicine
business
Mathematics
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....17c3fcb2845e006e6b948a719dbb5d7c