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Heart Transplantation Survival Outcomes of HIV Positive and Negative Recipients
- Source :
- Ann Thorac Surg
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- BACKGROUND: In the era of antiretroviral therapy, HIV-positive patients have reduced mortality from HIV infection and increased morbidity from end stage heart failure. The number of HIV-positive heart transplantation recipients remains scant. Long-term survival has not been rigorously studied. We compared survival outcomes of heart transplantation in HIV-positive recipients to HIV-negative recipients. METHODS: Clinical data from all adult heart transplantations were extracted from the UNOS Dataset. The impact of recipient HIV status was analyzed with Cox proportional hazards modeling, 1:3 propensity score matching and Kaplan-Meier survival analysis. RESULTS: Seventy-five HIV-positive recipients and 29,848 HIV-negative recipients were identified. Race distributions differed between the recipient groups, with Blacks comprising a larger proportion of the HIV-positive recipient group (46.7% versus 20.9%, p
- Subjects :
- Graft Rejection
Pulmonary and Respiratory Medicine
medicine.medical_specialty
medicine.medical_treatment
Human immunodeficiency virus (HIV)
HIV Infections
030204 cardiovascular system & hematology
medicine.disease_cause
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Survival analysis
Immunosuppression Therapy
Heart transplantation
Proportional hazards model
business.industry
COVID-19
virus diseases
medicine.disease
Transplant Recipients
030228 respiratory system
Heart failure
Propensity score matching
Heart Transplantation
Surgery
Hiv status
Cardiology and Cardiovascular Medicine
Serostatus
business
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 00034975
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- The Annals of Thoracic Surgery
- Accession number :
- edsair.doi.dedup.....17c0da31b54e484babba95b960b5ae1a