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Effects of intravenous l-carnitine on myocardial fatty acid imaging in hemodialysis patients: responders or non-responders to l-carnitine
- Source :
- SpringerPlus
- Publication Year :
- 2015
-
Abstract
- We investigated whether chronic intravenous administration of l-carnitine could improve myocardial fatty acid imaging in patients on maintenance hemodialysis. We enrolled 72 hemodialysis patients who had impaired myocardial fatty acid imaging and left ventricular dysfunction not based on coronary lesion. l-Carnitine (1,000 mg) was intravenously administered after dialysis for 1 year to 36 participants (Carnitine group), while not in the other 36 participants (Control group). Single-photon emission computed tomography (SPECT) using an iodinated fatty acid analogue, BMIPP, was performed. Uptake on SPECT images was graded in 17 segments on a five-point scale (0, normal; 4, absent) and assessed as BMIPP summed scores. During follow-up, 19 participants were discontinued from the study, and 53 participants (65 ± 12 years: 27 carnitine, 26 control) were analyzed. The mean BMIPP summed scores 1 year after carnitine administration did not differ from that before in the carnitine group, nor from that in the control group. However, improved SPECT (Changes in BMIPP summed scores
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Serum albumin
Gastroenterology
Imaging
Lesion
Internal medicine
Carnitine
medicine
Hypoalbuminemia
Dialysis
chemistry.chemical_classification
Multidisciplinary
biology
business.industry
Research
Fatty acid
Heart
Odds ratio
Uremic cardiomyopathy
medicine.disease
Surgery
chemistry
biology.protein
Hemodialysis
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 21931801
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- SpringerPlus
- Accession number :
- edsair.doi.dedup.....17a6a46d91d2156dc23e40fd06a553eb