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The Many Pathways of RNA Degradation
- Source :
- Cell. 136:763-776
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- From the earliest comparisons of RNA production with steady-state levels, it has been clear that cells transcribe more RNA than they accumulate, implying the existence of active RNA degradation systems. In general, RNA is degraded at the end of its useful life, which is long for a ribosomal RNA but very short for excised introns or spacer fragments, and is closely regulated for most mRNA species. RNA molecules with defects in processing, folding, or assembly with proteins are identified and rapidly degraded by the surveillance machinery. Because RNA degradation is ubiquitous in all cells, it is clear that it must be carefully controlled to accurately recognize target RNAs. How this is achieved is perhaps the most pressing question in the field.
- Subjects :
- Riboswitch
0303 health sciences
RNA Stability
Transcription, Genetic
RNA-induced transcriptional silencing
Biochemistry, Genetics and Molecular Biology(all)
Intron
RNA
Biology
Molecular biology
General Biochemistry, Genetics and Molecular Biology
Cell biology
03 medical and health sciences
RNA silencing
0302 clinical medicine
Ribonucleoproteins
RNA editing
Animals
Humans
Metabolic Networks and Pathways
030217 neurology & neurosurgery
Small nuclear RNA
030304 developmental biology
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 136
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....179325957ea9e6a7f26f8f959ef72d1a