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HDL, ABC Transporters, and Cholesterol Efflux: Implications for the Treatment of Atherosclerosis
- Source :
- Cell Metabolism. (5):365-375
- Publisher :
- Elsevier Inc.
-
Abstract
- High-density lipoprotein (HDL) has been identified as a potential target in the treatment of atherosclerotic vascular disease. The failure of torcetrapib, an inhibitor of cholesteryl ester transfer protein (CETP) that markedly increased HDL levels in a clinical trial, has called into doubt the efficacy of HDL elevation. Recent analysis suggests that failure may have been caused by off-target toxicity and that HDL is functional and promotes regression of atherosclerosis. New studies highlight the central importance of the ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 in reducing macrophage foam cell formation, inflammation, and atherosclerosis. A variety of approaches to increasing HDL may eventually be successful in treating atherosclerosis.
- Subjects :
- miR-33
medicine.medical_specialty
Physiology
chemistry.chemical_compound
Internal medicine
Cholesterylester transfer protein
medicine
Animals
Humans
Molecular Biology
Foam cell
biology
Cholesterol
Torcetrapib
nutritional and metabolic diseases
Cell Biology
Atherosclerosis
Endocrinology
ABCG1
chemistry
ABCA1
biology.protein
ATP-Binding Cassette Transporters
lipids (amino acids, peptides, and proteins)
Lipoproteins, HDL
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 15504131
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cell Metabolism
- Accession number :
- edsair.doi.dedup.....1786e87f9845d0cdf7dc360254593682
- Full Text :
- https://doi.org/10.1016/j.cmet.2008.03.001