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Development of Hypercalcemic Crisis in a Graves' Hyperthyroid Patient Associated with Central Diabetes Insipidus
- Source :
- Internal Medicine. 34:924-928
- Publication Year :
- 1995
- Publisher :
- Japanese Society of Internal Medicine, 1995.
-
Abstract
- A 26-year-old man with Graves' hyperthyroidism associated with central diabetes insipidus (DI), initially showed hypercalcemic crisis. Initially, very low serum levels of intact parathyroid hormone (PTH) and 1, 25-dihydroxy vitamin D3 and a moderate rise of serum C-terminal PTH related protein (C-PTHrP) were observed which strongly suggested a humoral hypercalcemia of malignancy due to PTHrP. However, the serum C-PTHrP level later became normal. Mild hyperprolactinemia, no responses of growth hormone (GH) to insulin-induced hypoglycemia despite a normal growth hormone releasing hormone (GRH) test and mild thickening of the pituitary stalk on magnetic resonance imaging were observed. Thus, an autoimmune nature of his central DI is considered; it is noteworthy that the serum C-PTHrP level may be elevated by renal failure in patients with hypercalcemia due to causes other than PTHrP.(Internal Medicine 34: 924-928, 1995)
- Subjects :
- Adult
Male
musculoskeletal diseases
medicine.medical_specialty
endocrine system diseases
Graves' disease
Hypoglycemia
Malignancy
Internal medicine
Internal Medicine
medicine
Humans
Pituitary stalk
Autoimmune disease
business.industry
Metabolic disorder
Parathyroid Hormone-Related Protein
Proteins
General Medicine
medicine.disease
Graves Disease
Endocrinology
Parathyroid Hormone
Acute Disease
Diabetes insipidus
Hypercalcemia
business
Diabetes Insipidus
hormones, hormone substitutes, and hormone antagonists
Hormone
Subjects
Details
- ISSN :
- 13497235 and 09182918
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi.dedup.....1783e55abe77a66af92e4a88e1ac8893