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Characteristics and prognostic significance of incidentally detected cancer cells in uterine specimens of patients with pelvic highâgrade serous carcinoma
- Source :
- Cytopathology. 31:122-129
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- OBJECTIVE Cases of pelvic high-grade serous carcinoma (HGSC) with incidentally detected cancer cells (ICCs) in endometrial and/or cervicovaginal cytology have been reported. This study aimed to clarify the incidence and characteristics of pelvic HGSC with ICCs and to determine whether ICCs have a negative prognostic impact. METHODS Patients with ovarian/tubal/peritoneal HGSC who underwent pre-treatment uterine (endometrial/cervicovaginal) cytology or biopsy between January 2007 and May 2017 were included. We reviewed the frequencies of ICCs and compared the clinicopathological features and survival outcome between the ICC-positive and ICC-negative groups. RESULTS Of the 160 patients evaluated, 69 (43.2%) had positive ICCs in at least one uterine specimen. There were no significant differences in clinicopathological characteristics, such as age, FIGO stage, serum CA125 level, ascites, and tubal lesion, between the two groups. Moreover, ICCs had no significant survival impact on progression-free survival or overall survival. CONCLUSION Our study showed a high rate of pelvic HGSC with ICCs in pre-treatment uterine specimens. The ICCs per se had no negative impact on survival outcomes of pelvic HGSC. Furthermore, uterine biopsy and cytology can be useful and less-invasive methods to obtain tubo-ovarian/peritoneal cancer cells before treatment.
- Subjects :
- Adult
Male
medicine.medical_specialty
Histology
Serous carcinoma
Cytodiagnosis
Gastroenterology
Pathology and Forensic Medicine
Lesion
Cytology
Internal medicine
Ascites
Biopsy
medicine
Humans
Stage (cooking)
Aged
Pelvic Neoplasms
Aged, 80 and over
medicine.diagnostic_test
business.industry
Incidence (epidemiology)
General Medicine
Middle Aged
Prognosis
medicine.disease
Progression-Free Survival
Cystadenocarcinoma, Serous
Female
Neoplasm Grading
medicine.symptom
Ovarian cancer
business
Subjects
Details
- ISSN :
- 13652303 and 09565507
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Cytopathology
- Accession number :
- edsair.doi.dedup.....17816c95fd31ca991e203c487cfda066
- Full Text :
- https://doi.org/10.1111/cyt.12796