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Two mammalian mitotic aurora kinases : who's who?
- Source :
- Science's STKE : signal transduction knowledge environment, Science's STKE : signal transduction knowledge environment, American Association for the Advancement of Science, 2001, 73, pp.PE1, Science's STKE [electronic resource] : signal transduction knowledge environment, Science's STKE [electronic resource] : signal transduction knowledge environment, 2001, 2001 (73), pe1. ⟨10.1126/stke.2001.73.pe1⟩
- Publication Year :
- 2001
- Publisher :
- HAL CCSD, 2001.
-
Abstract
- International audience; Several serine-threonine kinases related to the Ipl1p kinase in budding yeast, termed aurora kinases, have been cloned recently. Their characterization revealed them to be important regulators of mitotic functions, including (i) the separation of the centrosome, (ii) assembly of the spindles, and (iii) segregation of the chromosomes. The Perspective by Descamps and Prigent delves into the latest observations on aurora kinases in humans and the specific roles of each kinase within the process of mitosis.
- Subjects :
- Extracellular signal-regulated kinases
[SDV]Life Sciences [q-bio]
Maturation-Promoting Factor
Aurora B kinase
Aurora inhibitor
Mitosis
Cell Cycle Proteins
Polo-like kinase
macromolecular substances
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Protein Serine-Threonine Kinases
Biology
Biochemistry
MESH: Centrosome
Gene Expression Regulation, Enzymologic
MESH: Protein-Serine-Threonine Kinases
03 medical and health sciences
MESH: Aurora Kinases
0302 clinical medicine
MESH: Cell Cycle Proteins
Aurora Kinases
Animals
Humans
MESH: Animals
[INFO]Computer Science [cs]
Kinetochores
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
Molecular Biology
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Centrosome
0303 health sciences
MESH: Humans
Kinase
MESH: Kinetochores
MESH: Gene Expression Regulation, Enzymologic
MESH: Maturation-Promoting Factor
Cell Biology
General Medicine
MESH: Mitosis
Budding yeast
Cell biology
030220 oncology & carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 15258882
- Database :
- OpenAIRE
- Journal :
- Science's STKE : signal transduction knowledge environment, Science's STKE : signal transduction knowledge environment, American Association for the Advancement of Science, 2001, 73, pp.PE1, Science's STKE [electronic resource] : signal transduction knowledge environment, Science's STKE [electronic resource] : signal transduction knowledge environment, 2001, 2001 (73), pe1. ⟨10.1126/stke.2001.73.pe1⟩
- Accession number :
- edsair.doi.dedup.....17795ace8bf3068b1a31834f8e14b441
- Full Text :
- https://doi.org/10.1126/stke.2001.73.pe1⟩