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Neuropeptide S produces hyperlocomotion and prevents oxidative stress damage in the mouse brain: A comparative study with amphetamine and diazepam
- Publication Year :
- 2009
-
Abstract
- Neuropeptide S (NPS) is a recently discovered peptide which induces hyperlocomotion, anxiolysis and wakefulness. This study aimed to compare behavioral and biochemical effects of NPS with amphetamine (AMPH), and diazepam (DZP). To this aim, the effects of NPS (0.01, 0.1 and 1 nmol, ICV), AMPH (2 mg/kg, IP) and DZP (1 mg/kg, IP) on locomotion and oxidative stress parameters were assessed in mouse brain structures. The administration of NPS and AMPH, but not DZP, increased locomotion compared to control. Biochemical analyses revealed that AMPH increased carbonylated proteins in striatum, but did not alter lipid peroxidation. DZP increased lipid peroxidation in the cortex and cerebellum, and increased protein carbonyl formation in the striatum. In contrast, NPS reduced carbonylated protein in the cerebellum and striatum, and also lipid peroxidation in the cortex. Additionally, the treatment with AMPH increased superoxide dismutase (SOD) activity in the striatum, while it did not affect catalase (CAT) activity. DZP did not alter SOD and CAT activity. NPS inhibited the increase of SOD activity in the cortex and cerebellum, but little influenced CAT activity. Altogether, this is the first evidence of a putative role of NPS in oxidative stress and brain injury.
- Subjects :
- Male
Locomotor activity
Clinical Biochemistry
Central nervous system
Lipid peroxidation
Neuropeptide
Nerve Tissue Proteins
Striatum
Superoxide dismutase
Motor Activity
Pharmacology
Toxicology
medicine.disease_cause
Biochemistry
Protein Carbonylation
Mice
Behavioral Neuroscience
chemistry.chemical_compound
Brain structures
Neuropeptide S
medicine
Animals
Hypnotics and Sedatives
Amphetamine
Biological Psychiatry
Injections, Intraventricular
Brain Chemistry
Diazepam
biology
Chemistry
Neuropeptides
technology, industry, and agriculture
Catalase
medicine.anatomical_structure
Oxidative stress
biology.protein
Protein carbonyls
Central Nervous System Stimulants
Injections, Intraperitoneal
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1777a18fd8b6ef0193a9a69bec312767