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Treatment of cutaneous melanoma harboring smo p.Gln216arg mutation with imiquimod: An old drug with new results
- Source :
- Journal of Personalized Medicine, Vol 11, Iss 206, p 206 (2021), Journal of Personalized Medicine
- Publication Year :
- 2021
-
Abstract
- Melanoma is the most lethal form of skin cancer and its incidence is growing worldwide. In the last ten years, the therapeutic scenario of this disease has been revolutionized by the introduction of targeted therapies and immune-checkpoint inhibitors. However, in patients with many lesions and bulky tumors, in which surgery is no longer feasible, there is a need for new treatment options. Here we report, for the first time to our knowledge, a clinical case where a melanoma patient harboring the SMO p.Gln216Arg mutation has been treated with imiquimod, showing a complete and durable response. To better explain this outstanding response to the treatment, we transfected a melanoma cell line (MeWo) with the SMO p.Gln216Arg mutation in order to evaluate its role in response to the imiquimod treatment. Moreover, to better demonstrate that the antitumor activity of imiquimod was due to its role in suppressing the oncogenic SMO signaling pathway, independently of its immune modulating function, an in vivo experiment has been performed. This clinical case opens up a new scenario for the treatment of melanoma patients identifying a new potentially druggable target.
- Subjects :
- Druggability
lcsh:Medicine
Medicine (miscellaneous)
Case Report
Imiquimod
Disease
medicine.disease_cause
Hedgehog pathway
03 medical and health sciences
0302 clinical medicine
Immune system
Medicine
Melanoma
030304 developmental biology
0303 health sciences
Mutation
business.industry
lcsh:R
SMO
medicine.disease
030220 oncology & carcinogenesis
Cutaneous melanoma
Cancer research
Skin cancer
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Personalized Medicine, Vol 11, Iss 206, p 206 (2021), Journal of Personalized Medicine
- Accession number :
- edsair.doi.dedup.....176707ec3a9b0220ab1243e7137e3160