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Psoriatic arthritis: treatment strategies using biologic agents
- Source :
- Reumatismo, Vol 64, Iss 2, Pp 113-121 (2012)
- Publication Year :
- 2012
-
Abstract
- The traditional management of psoriatic arthritis (PsA) includes NSAIDs, corticosteroids and DMARDs. Advancement in the knowledge of the immunopathogenesis of PsA has been associated with the development of biologic agents which have revolutionized the management of the disease. Among biologics drugs, there are the 4 currently availablee anti-TNFα blocking agents (etanercept, infliximab, adalimumab and golimumab) which are more effective than traditional DMARDs on symptoms/signs of inflammation, quality of life, function, and in inhibiting the progression of the structural joint damage. Despite of the high cost, TNF inhibitors are costeffective on both the musculoskeletal and skin manifestations of psoriatic disease.
- Subjects :
- musculoskeletal diseases
medicine.medical_specialty
lcsh:Internal medicine
lcsh:Medicine
Disease
Antibodies, Monoclonal, Humanized
Lymphocyte Depletion
Receptors, Tumor Necrosis Factor
Etanercept
Psoriatic arthritis
Biological Factors
Rheumatology
Quality of life
immune system diseases
medicine
Adalimumab
Humans
skin and connective tissue diseases
lcsh:RC31-1245
Clinical Trials as Topic
Receptor Activator of Nuclear Factor-kappa B
business.industry
Tumor Necrosis Factor-alpha
Interleukins
lcsh:R
Arthritis, Psoriatic
RANK Ligand
Antibodies, Monoclonal
medicine.disease
Dermatology
Infliximab
Golimumab
Immunoglobulin G
Practice Guidelines as Topic
Tumor necrosis factor alpha
business
medicine.drug
Psoriatic disease, psoriatic arthritis, therapy, biologic drugs, anti-TNFα agents
Subjects
Details
- ISSN :
- 00487449
- Volume :
- 64
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Reumatismo
- Accession number :
- edsair.doi.dedup.....175d720d889d2b3fdc2265ea79908c92