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Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro
- Source :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 36(11)
- Publication Year :
- 2016
-
Abstract
- Cerebrovascular dysfunction is a critical component of Alzheimer’s disease (AD) pathogenesis. Oligomeric amyloid-β42 (oAβ42) is considered a major contributor to AD progression. However, data are limited on the role of oAβ42 in brain endothelial cell vessel degeneration/angiogenesis, including the interaction with angiogenic mediators. Thus, the current study determined the effect of oAβ42 on angiogenesis in vitro, utilizing single brain endothelial cell cultures and triple cultures mimicking the microvascular unit (MVU: brain endothelial cells, astrocytes, and pericytes). oAβ42 dose-dependently reduced angiogenesis and induced vessel disruption. Critically, epidermal growth factor prevented oAβ42-induced deficits, implicating angiogenic pathways as potential therapeutics for AD.
- Subjects :
- 0301 basic medicine
Amyloid β
Endothelium
Angiogenesis
Neovascularization, Physiologic
Blood–brain barrier
Brief Communication
Models, Biological
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Epidermal growth factor
Alzheimer Disease
medicine
Humans
Cells, Cultured
Amyloid beta-Peptides
Dose-Response Relationship, Drug
Epidermal Growth Factor
Chemistry
Endothelial Cells
In vitro
Coculture Techniques
Peptide Fragments
Endothelial stem cell
030104 developmental biology
medicine.anatomical_structure
Neurology
Astrocytes
Immunology
Microvessels
Cancer research
Neurology (clinical)
Endothelium, Vascular
Protein Multimerization
Cardiology and Cardiovascular Medicine
Pericytes
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15597016
- Volume :
- 36
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Accession number :
- edsair.doi.dedup.....175986c4d2cdd192b68753a01ea2435c