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Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro

Authors :
Riya Thomas
Kevin P. Koster
Alan Morris
Leon M. Tai
Source :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 36(11)
Publication Year :
2016

Abstract

Cerebrovascular dysfunction is a critical component of Alzheimer’s disease (AD) pathogenesis. Oligomeric amyloid-β42 (oAβ42) is considered a major contributor to AD progression. However, data are limited on the role of oAβ42 in brain endothelial cell vessel degeneration/angiogenesis, including the interaction with angiogenic mediators. Thus, the current study determined the effect of oAβ42 on angiogenesis in vitro, utilizing single brain endothelial cell cultures and triple cultures mimicking the microvascular unit (MVU: brain endothelial cells, astrocytes, and pericytes). oAβ42 dose-dependently reduced angiogenesis and induced vessel disruption. Critically, epidermal growth factor prevented oAβ42-induced deficits, implicating angiogenic pathways as potential therapeutics for AD.

Details

ISSN :
15597016
Volume :
36
Issue :
11
Database :
OpenAIRE
Journal :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Accession number :
edsair.doi.dedup.....175986c4d2cdd192b68753a01ea2435c