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Toxicological evaluation of l-proline in a 90-day feeding study with Fischer 344 rats
- Source :
- Regulatory Toxicology and Pharmacology. 58:114-120
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- L-proline (L-Pro) is a non-essential amino acid, and has become widely used as supplements and health foods, recently. A subchronic oral toxicity study of L-Pro was conducted with groups of 10 male and 10 female Fischer 344 rats fed a powder diet containing 0%, 0.625%, 1.25%, 2.5% and 5.0% of L-Pro for 90 days. No treatment-related clinical signs and mortality were noted. We observed no clear treatment-related effects with regard to body weight, food intake or urinalysis data. The average daily water intakes of the treated female groups were significantly increased compared to the controls. The hematology (red blood cell parameter) and serum biochemistry (glucose, blood urea nitrogen, creatinine or uric acid) of the treated male and/or female groups were lower than those of the control groups. However, these changes were lacked dose-dependence, and no abnormalities were found in corresponding pathological findings. In conclusion, the no-observed-adverse-effect-level (NOAEL) for L-Pro was determined to be a dietary dose of 5.0% (2772.9 mg/kg body weight/day for males and 3009.3mg/kg body weight/day for females) under the present experimental conditions.
- Subjects :
- Male
medicine.medical_specialty
Proline
Urinalysis
Physiology
Biology
Kidney
Toxicology
chemistry.chemical_compound
Sex Factors
Internal medicine
Toxicity Tests
medicine
Animals
Blood urea nitrogen
Creatinine
Hematologic Tests
Hematology
medicine.diagnostic_test
Body Weight
Organ Size
General Medicine
Rats, Inbred F344
Rats
Red blood cell
medicine.anatomical_structure
chemistry
Dietary Supplements
Toxicity
Uric acid
Female
Spleen
Subjects
Details
- ISSN :
- 02732300
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Regulatory Toxicology and Pharmacology
- Accession number :
- edsair.doi.dedup.....1745c8e64f431800d88be867b27c0bba