Additional file 1: of Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

Figure S1. Evaluation of the ascorbic acid dose proportionality in part 1 of the study. The mean AA Cmax and AUC are presented vs increasing doses of AA (measured after the first administered dose of AA) on day 1 and day 3. AUC 0â 9: area under the plasma concentration-time curve from time zero to hour 9; Cmax: maximum plasma concentration. (PDF 21 kb)