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Spontaneous resolution of schitic cavities in XLRS
- Source :
- Ophthalmic Genetics. 42:765-767
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- X-linked retinoschisis (XLRS) is an inherited retinal condition that leads to schisis of the retina. In the past, treatment trials for XLRS have generally used OCT monitoring of the schitic cavities as the primary structural outcome measure and best corrected visual acuity as the primary functional outcome. Here, we report two cases of genetically confirmed XLRS with marked fluctuations in OCT morphology in the absence of treatment. Given this demonstration of spontaneous fluctuation in retinal structure on OCT in XLRS we suggest that alternative measures of retinal function should be used in future therapeutic trials in XLRS.
- Subjects :
- Male
medicine.medical_specialty
genetic structures
Retinoschisis
Remission, Spontaneous
Visual Acuity
Polymorphism, Single Nucleotide
Retina
Young Adult
chemistry.chemical_compound
Ophthalmology
Electroretinography
Humans
Medicine
Genetic Testing
Child
Eye Proteins
Genetics (clinical)
Best corrected visual acuity
business.industry
Outcome measures
Retinal
medicine.disease
Therapeutic trial
eye diseases
medicine.anatomical_structure
Retinal structure
chemistry
Pediatrics, Perinatology and Child Health
Retinal function
sense organs
business
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 17445094 and 13816810
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Ophthalmic Genetics
- Accession number :
- edsair.doi.dedup.....17281d68b7a613ef734ee111974f90fe