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Pefloxacin and vancomycin vs. gentamicin, colistin sulphate and vancomycin for prevention of infections in granulocytopenic patients: a randomised double-blind study
- Source :
- European journal of cancer (Oxford, England : 1990). 27(2)
- Publication Year :
- 1991
-
Abstract
- To test the value of pefloxacin for the prevention of infections in patients with chemotherapy-induced neutropenia, oral pefloxacin plus vancomycin (PV) (n=76) or gentamicin, colistin sulphate and vancomycin (GCV) (n=74) were administered in a randomised double-blind study. Infections were significantly less severe in the PV than in the GCV group. Patients receiving PV had significantly fewer episodes of bacteraemia and central venous line infections than patients treated with GVC. Gram-positive and gram-negative infections were significantly less frequent in patients receiving PV, because of fewer infections with Staphylococcus species and enterobacteriaceae. Stool culture detected significantly more gram-positive organisms in the PV group and more gram-negative organisms in the GCV group. Thus, PV was more efficacious than GCV for the prevention of gram-positive and gram-negative infections in the neutropenic patients, despite lower efficacy in eradicating gram-positive organisms from the lower intestinal tract.
- Subjects :
- Colistin sulphate
Adult
Male
medicine.medical_specialty
Neutropenia
medicine.drug_class
viruses
medicine.medical_treatment
Antibiotics
Antineoplastic Agents
Gastroenterology
Pefloxacin
Double-Blind Method
Vancomycin
Internal medicine
Medicine
Humans
Aged
Chemotherapy
business.industry
Colistin
Bacterial Infections
Middle Aged
medicine.disease
Surgery
Oncology
Gentamicin
Drug Therapy, Combination
Female
Gentamicins
business
Complication
medicine.drug
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 27
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Accession number :
- edsair.doi.dedup.....17231895acaec31dc0077a11a7f9aa6b