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Multiplex Analysis on a Single Porous Hydrogel Bead with Encoded SERS Nanotags
- Source :
- ACS applied materialsinterfaces. 10(1)
- Publication Year :
- 2017
-
Abstract
- Bead-based assays have drawn more and more attention in biomedical fields. Herein, we proposed a novel approach to achieve multiplex analysis on a single porous hydrogel bead (PHB) with Raman dyes (RDs) encoded core-shell surface-enhanced Raman scattering (SERS) nanotags. Because of the amplified signal of RDs by core-shell metal structure of the nanotag and the high surface area to volume ratio (SVR) of the PHB, the sensitivity and linear dynamic range (LDR) of the as-proposed multiplex analysis method are significantly improved. We anticipate this approach to be widely used in the multiplex assays and biosensors.
- Subjects :
- Materials science
Dynamic range
technology, industry, and agriculture
Nanotechnology
macromolecular substances
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Bead (woodworking)
symbols.namesake
symbols
High surface area
General Materials Science
Multiplex
0210 nano-technology
Raman spectroscopy
Biosensor
Raman scattering
Porous hydrogel
Subjects
Details
- ISSN :
- 19448252
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- ACS applied materialsinterfaces
- Accession number :
- edsair.doi.dedup.....171f86ebcc3d4b8b7fb462ce738dcccf