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Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release
- Source :
- Journal of Polymer Science Part A: Polymer Chemistry. 56:59-66
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Cationic, amphiphilic microgels of differing compositions based on hydrophilic, pH, and thermoresponsive 2-(dimethylamino)ethyl methacrylate (DMAEMA) and hydrophobic, nonionic n-butyl acrylate (BuA) are synthesized using a lab-on-a-chip device. Hydrophobic oil-in-water (o/w) droplets are generated via a microfluidic platform, with the dispersed (droplet) phase containing the DMAEMA and BuA, alongside the hydrophobic cross-linker, ethylene glycol dimethacrylate, and a free radical initiator in an organic solvent. Finally, the hydrophobic droplets are photopolymerized via a UV light source as they traverse the microfluidic channel to produce the cationic amphiphilic microgels. This platform enables the rapid, automated, and in situ production of amphiphilic microgels, which do not match the core-shell structure of conventionally prepared microgels but are instead based on random amphiphilic copolymers of DMAEMA and BuA between the hydrophobic cross-links. The microgels are characterized in terms of their swelling and encapsulation abilities, which are found to be influenced by both the pH response and the hydrophobic content of the microgels. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 59–66.
- Subjects :
- Acrylate
Polymers and Plastics
Polymers
Chemistry
Ethylene glycol dimethacrylate
Organic Chemistry
Cationic polymerization
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Methacrylate
01 natural sciences
0104 chemical sciences
chemistry.chemical_compound
Photopolymer
Chemical engineering
Amphiphile
Materials Chemistry
medicine
Radical initiator
Swelling
medicine.symptom
0912 Materials Engineering
0210 nano-technology
0303 Macromolecular And Materials Chemistry
Subjects
Details
- ISSN :
- 0887624X
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Journal of Polymer Science Part A: Polymer Chemistry
- Accession number :
- edsair.doi.dedup.....171f0010713cd570e262bf362bcc5ae6