Back to Search
Start Over
Radical cytoreductive prostatectomy in men with prostate cancer and oligometastatic disease
- Source :
- Current opinion in urology. 30(1)
- Publication Year :
- 2019
-
Abstract
- Purpose of review Local treatment of the primary by either radical prostatectomy or radiation therapy is discussed controversially. The role of cytoreductive radical prostatectomy has been evaluated in few retrospective clinical studies but data of prospective randomized clinical phase-III trials are lacking. It is the purpose of this review to reflect the current knowledge on indication, functional and oncological outcomes of cytoreductive radical prostatectomy to objectively highlight what can be expected from this approach. Recent findings Cytoreductive radical prostatectomy (cRP) is associated with a long overall survival of more than 7 years and it is associated with a clinical progression-free survival of more than 6 years. When compared with nonsurgical approaches it becomes evident that about one-third of the patients will develop symptomatic local progression within 3 years whereas none of the surgically treated patients will experience such symptoms. cRP is associated with a low rate of significant complications and good functional outcome in well selected patients which do not differ from the results of a radical prostatectomy in treatment-naive patients. Summary Patients with low-volume/low-risk metastatic prostate cancer (mPCA), good response to neoadjuvant androgen deprivation therapy and a good Eastern Cooperative Onology Group performance status appear to be the best candidates for surgery. cRP might be an individualized treatment option in the multimodality management of mPCA. It is the purpose of the current to highlight the indication, surgical technique, treatment associated complications, functional and oncological outcome for cytoreductive radical prostatectomy.
- Subjects :
- Oncology
Male
medicine.medical_specialty
Urology
medicine.medical_treatment
030232 urology & nephrology
MEDLINE
Androgen deprivation therapy
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Internal medicine
medicine
Overall survival
Humans
Group performance
Oligometastatic disease
Prostatectomy
business.industry
Prostatic Neoplasms
Androgen Antagonists
Cytoreduction Surgical Procedures
medicine.disease
Radiation therapy
030220 oncology & carcinogenesis
business
Subjects
Details
- ISSN :
- 14736586
- Volume :
- 30
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Current opinion in urology
- Accession number :
- edsair.doi.dedup.....171adcca289619d77edacbd1ab78a04a