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MS-681a, b, c and d, New Inhibitors of Myosin Light Chain Kinase from Myrothecium sp. KY6568. I. Characterization of Producing Strain and Production, Isolation and Biological Activities

Authors :
Yutaka Saitoh
Yoji Ikuina
Satoshi Nakanishi
Hiroshi Yano
Katsuhiko Ando
Yuzuru Matsuda
Mayumi Yoshida
Source :
The Journal of Antibiotics. 50:992-997
Publication Year :
1997
Publisher :
Japan Antibiotics Research Association, 1997.

Abstract

Novel compounds MS-681a, b, c and d were isolated from the culture broth of a fungal strain KY6568. The strain was identified as Myrothecium sp. from its morphological characteristics. MS-681a, b, c and d inhibited the activity of purified smooth muscle myosin light chain kinase with IC50 values of 0.11, 0.29, 0.095 and 0.26 microM, respectively. Cyclic AMP-dependent protein kinase, cyclic GMP-dependent protein kinase and protein kinase C were not inhibited at 100 microM by MS-681 compounds.

Details

ISSN :
18811469 and 00218820
Volume :
50
Database :
OpenAIRE
Journal :
The Journal of Antibiotics
Accession number :
edsair.doi.dedup.....171008444c9e6116b1426f75e1388ac4
Full Text :
https://doi.org/10.7164/antibiotics.50.992