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MS-681a, b, c and d, New Inhibitors of Myosin Light Chain Kinase from Myrothecium sp. KY6568. I. Characterization of Producing Strain and Production, Isolation and Biological Activities
- Source :
- The Journal of Antibiotics. 50:992-997
- Publication Year :
- 1997
- Publisher :
- Japan Antibiotics Research Association, 1997.
-
Abstract
- Novel compounds MS-681a, b, c and d were isolated from the culture broth of a fungal strain KY6568. The strain was identified as Myrothecium sp. from its morphological characteristics. MS-681a, b, c and d inhibited the activity of purified smooth muscle myosin light chain kinase with IC50 values of 0.11, 0.29, 0.095 and 0.26 microM, respectively. Cyclic AMP-dependent protein kinase, cyclic GMP-dependent protein kinase and protein kinase C were not inhibited at 100 microM by MS-681 compounds.
- Subjects :
- Pharmacology
chemistry.chemical_classification
Aminoisobutyric Acids
Myosin light-chain kinase
Strain (chemistry)
Spermidine
Biological activity
Biology
Enzyme
chemistry
Biochemistry
Enzyme inhibitor
Hypocreales
Drug Discovery
biology.protein
Enzyme Inhibitors
Peptides
Protein kinase A
Myosin-Light-Chain Kinase
Protein kinase C
Antibacterial agent
Subjects
Details
- ISSN :
- 18811469 and 00218820
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- The Journal of Antibiotics
- Accession number :
- edsair.doi.dedup.....171008444c9e6116b1426f75e1388ac4
- Full Text :
- https://doi.org/10.7164/antibiotics.50.992