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Aggregation of stomach cancer history in parents and offspring in comparison with other sites
- Source :
- International Journal of Epidemiology. 32:579-583
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- Background The aim of this study is to evaluate the magnitude of the aggregation of a stomach cancer history in parents and their offspring in comparison with that of a history at other sites. Methods We used the baseline data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated during 1988-1990 in Japan. Association of the cancer history of the subjects' parents with that of the subjects themselves and any of the subjects' siblings was evaluated with odds ratios (OR) by the crude and generalized estimating equations (GEE) technique for four sites: stomach, colorectum, liver, and lung/bronchus. Results The aggregation of a history of stomach cancer between parents and their offspring was evident with significant OR >2.5. The magnitude of the parent-offspring association of a disease history of the colorectum and liver was found to be greater than that for stomach cancer. Conversely, lung and bronchus cancer failed to demonstrate a significant aggregation. Conclusions The hereditary and environmental influences shared by parents and offspring are likely to play a strong aetiological role in colorectal or liver cancer versus a weaker but still significant role in stomach cancer. In contrast, the aetiological role of familial predisposition to lung cancer was indeterminate, which suggests a predominant role of non-familial factors in the development of lung cancer.
- Subjects :
- Adult
Male
Parents
Risk
medicine.medical_specialty
Lung Neoplasms
Epidemiology
Offspring
Physiology
Gastroenterology
Stomach Neoplasms
Internal medicine
Odds Ratio
medicine
Humans
Genetic Predisposition to Disease
Lung cancer
Stomach cancer
Aged
Family Health
business.industry
Incidence
Siblings
Stomach
Bronchial Neoplasms
Liver Neoplasms
Cancer
Family aggregation
General Medicine
Odds ratio
Middle Aged
medicine.disease
medicine.anatomical_structure
Female
Birth Order
Colorectal Neoplasms
Liver cancer
business
Subjects
Details
- ISSN :
- 14643685 and 03005771
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- International Journal of Epidemiology
- Accession number :
- edsair.doi.dedup.....170ef11d16999d86746c9d45cf5ff658