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Total and Unbound Doravirine Concentrations and Viral Suppression in CSF
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 74(10)
- Publication Year :
- 2021
-
Abstract
- We determined total and unbound concentrations of doravirine (DOR) in cerebrospinal fluid and blood plasma. Total and unbound DOR concentrations in cerebrospinal fluid exceeded the half-maximal effective concentration against wild-type virus (5.1 ng/mL) in all patients, suggesting that DOR may contribute to inhibit viral replication in this compartment.
- Subjects :
- Microbiology (medical)
medicine.medical_specialty
business.industry
Pyridones
Human immunodeficiency virus (HIV)
HIV Infections
Triazoles
medicine.disease_cause
Virus Replication
Virus
Infectious Diseases
Endocrinology
Cerebrospinal fluid
Viral replication
Internal medicine
Blood plasma
HIV-1
Medicine
Humans
business
EC50
Subjects
Details
- ISSN :
- 15376591
- Volume :
- 74
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....170992c3cbb612b9180c6ce7b6514d9b