Back to Search
Start Over
Influence of systemic bone mineral density on atlantoaxial subluxation in patients with rheumatoid arthritis
- Source :
- Osteoporosis International. 28:1931-1938
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Osteopenia and osteoporosis were independent predictive factors for higher atlantoaxial subluxation occurrence in patients with lower body mass index. Our findings suggest that patients with rheumatoid arthritis with osteopenia or osteoporosis, particularly those with lower body mass index (BMI), should be screened regularly to determine the status of their cervical spines. Cervical spine involvement in rheumatoid arthritis (RA) patients may cause serious adverse effects on quality of life and overall health. This study aimed to evaluate the association between atlantodental interval (ADI), atlantoaxial subluxation (AAS), and systemic bone mineral density (BMD) based on BMI variations among established patients with RA. The ADI was transformed to the natural log scale to normalize distributions for all analyses. Multivariable linear regression analyses were used to identify independent predictive factors for ADI based on each BMD classification. Multivariate Cox regression analyses were also performed to identify independent predictive factors for the risk of AAS, which were classified by tertile groups of BMI. A total of 1220 patients with RA who had undergone at least one or more cervical radiography and BMD assessments were identified and enrolled. We found that the association between BMD and ADI (β, −0.029; 95% CI, −0.059 to 0.002; p = 0.070) fell short of achieving statistical significance. However, the ADI showed a 3.6% decrease per 1 BMI increase in the osteoporosis group (β, −0.036; 95% CI, −0.061 to −0.011; p = 0.004). The osteopenia and osteoporosis groups showed about a 1.5-fold and a 1.8-fold increased risk of AAS occurrence among the first tertile of the BMI group. Our study showed a possible association between lower BMD and AAS occurrence in patients with RA with lower BMI. Further studies are needed to confirm our findings.
- Subjects :
- Joint Instability
Male
musculoskeletal diseases
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Osteoporosis
Joint Dislocations
Body Mass Index
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Quality of life
Bone Density
Rheumatoid Factor
Internal medicine
Statistical significance
medicine
Humans
Mass index
Aged
Retrospective Studies
030203 arthritis & rheumatology
Bone mineral
Proportional hazards model
business.industry
Middle Aged
medicine.disease
Surgery
Osteopenia
Bone Diseases, Metabolic
Atlanto-Axial Joint
Antirheumatic Agents
Rheumatoid arthritis
Cervical Vertebrae
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14332965 and 0937941X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Osteoporosis International
- Accession number :
- edsair.doi.dedup.....16f8a748e40fcbeaebf4bd98eb6994ae