Back to Search
Start Over
Correlation between molecular analysis, diagnosis according to the 2015 WHO classification of unresected lung tumours and TTF1 expression in small biopsies and cytology specimens from 344 non-small cell lung carcinoma patients
- Source :
- Pathology. 49:604-610
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- We investigated correlations between diagnosis according to the 2015 World Health Organization (WHO) classification of unresected lung tumours, molecular analysis and TTF1 expression in small biopsy and cytology specimens from 344 non-small cell lung carcinoma (NSCLC) patients. One case failed testing for EGFR, KRAS and ALK abnormalities and six had insufficient tumour for ALK testing. Overall mutation rate in 343 cases was 48% for the genes tested, with 19% EGFR, 33% KRAS and 4% BRAF mutations, and 5% ALK rearrangements detected. More EGFR-mutant (78%) and ALK-rearranged (75%) tumours had morphologic adenocarcinoma than KRAS-mutant (56%) tumours. Despite no significant difference in the overall rate of any molecular abnormality between morphologic adenocarcinoma (52%) and NSCLC, favour adenocarcinoma (47%) (p = 0.18), KRAS mutations were detected more frequently in the latter group. No significant difference in the overall rate of any molecular abnormality between TTF1 positive (49%) and TTF1 negative tumours (44%) (p = 0.92) was detected, but more EGFR-mutant (97%) and ALK-rearranged tumours (92%) were TTF1 positive than KRAS-mutant tumours (68%). Rates of EGFR, KRAS and BRAF mutations and ALK rearrangements in this Australian NSCLC patient population are consistent with the published international literature. Our findings suggest that 2015 WHO classification of unresected tumours may assist in identifying molecular subsets of advanced NSCLC.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Lung Neoplasms
Biopsy
Adenocarcinoma
Biology
World Health Organization
medicine.disease_cause
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Unresected
Carcinoma, Non-Small-Cell Lung
Internal medicine
Cytology
medicine
Carcinoma
Humans
neoplasms
Aged
Aged, 80 and over
medicine.diagnostic_test
Australia
Cancer
Middle Aged
Molecular Abnormality
medicine.disease
Immunohistochemistry
digestive system diseases
respiratory tract diseases
DNA-Binding Proteins
030104 developmental biology
030220 oncology & carcinogenesis
Mutation
Female
KRAS
Transcription Factors
Subjects
Details
- ISSN :
- 00313025
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Pathology
- Accession number :
- edsair.doi.dedup.....16f0cbffd39554c570066e8992afecff