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Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome
- Source :
- Blood Cancer Journal, Blood Cancer Journal, Vol 11, Iss 5, Pp 1-9 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group UK, 2021.
-
Abstract
- Richter syndrome (RS) refers to transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma. RS is known to be associated with a number of genetic alterations such as TP53 and NOTCH1 mutations. However, it is unclear what immune microenvironment changes are associated with RS. In this study, we analyzed expression of immune checkpoint molecules and infiltration of immune cells in nodal samples, and peripheral blood T-cell diversity in 33 CLL and 37 RS patients. Compared to CLL, RS nodal tissue had higher PD-L1 expression in histiocytes and dendritic cells (median 16.6% vs. 2.8%, P P P P P = 0.046), suggesting that T cells in RS patients were significantly more diverse than in CLL patients. Collectively these data suggest that CLL and RS have distinct immune signatures. Better understanding of the immune microenvironment is essential to improve immunotherapy efficacy in CLL and RS.
- Subjects :
- Adult
Male
Chronic lymphocytic leukaemia
medicine.medical_treatment
Chronic lymphocytic leukemia
T-Lymphocytes
Programmed Cell Death 1 Receptor
Aggressive lymphoma
Article
B7-H1 Antigen
Immune system
hemic and lymphatic diseases
medicine
Tumor Microenvironment
Humans
Receptor
RC254-282
Histiocyte
Aged
Aged, 80 and over
B-Lymphocytes
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Hematology
Immunotherapy
Middle Aged
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma
Cell Transformation, Neoplastic
Oncology
Cancer research
Disease Progression
Tumour immunology
Female
Tumor Escape
Lymphoma, Large B-Cell, Diffuse
business
Infiltration (medical)
Subjects
Details
- Language :
- English
- ISSN :
- 20445385
- Volume :
- 11
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Blood Cancer Journal
- Accession number :
- edsair.doi.dedup.....16e701459225836b0c09482e48a86474