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A Green Synthesis of Carbene‐Metal‐Amides (CMAs) and Carboline‐Derived CMAs with Potent in vitro and ex vivo Anticancer Activity
- Source :
- ChemMedChem. 17
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- The modularity and ease of synthesis of carbene-metal-amide (CMA) complexes based on the coinage metals (Au, Ag, Cu) and N-heterocyclic carbenes (NHCs) as ancillary ligands pave the way for the expansion of their applications beyond photochemistry and catalysis. Herein, we further improve the synthesis of such compounds by circumventing the use of toxic organic solvents which were previously required for their purification, and we expand their scope to include complexes incorporating carbolines as the amido fragments. The novel complexes are screened both in vitro and ex vivo, against several cancer cell lines and high-grade serous ovarian cancer (HGSOC) tumoroids, respectively. Excellent cytotoxicity values are obtained for most complexes, while the structural variety of the CMA library screened thus far, provides promising leads for future developments. Variations of all three components (NHC, metal, amido ligand), enable the establishment of trends regarding cytotoxicity and selectivity towards cancerous over normal cells.
- Subjects :
- Amide
Cytotoxicity
Carbene-metal-amides
Coinage metal-N-heterocyclic carbene complexes
Green chemistry
Synthetic methods
Amides
Carbolines
Humans
Ligands
Metals
Methane
Molecular Structure
Heterocyclic Compounds
Neoplasms
Settore BIO/11 - Biologia Molecolare
Ligand
Biochemistry
Carbene-metal-amide
Drug Discovery
Coinage metal-N-heterocyclic carbene complexe
General Pharmacology, Toxicology and Pharmaceutics
Pharmacology
Synthetic method
Metal
Organic Chemistry
Heterocyclic Compound
Carboline
Molecular Medicine
Human
Subjects
Details
- ISSN :
- 18607187 and 18607179
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- ChemMedChem
- Accession number :
- edsair.doi.dedup.....16d3a4c0b5ff51b90acf07b1977de46b