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α-Internexin in the diagnosis of oligodendroglial tumors and association with 1p/19q status
- Source :
- Journal of neuropathology and experimental neurology. 70(11)
- Publication Year :
- 2011
-
Abstract
- α-Internexin (INA) has been proposed to be a surrogate marker for the 1p/19q codeletion in oligodendroglial tumors (OTs). We analyzed INA expression in 83 glioma and 21 oligodendroglial phenotype-mimicking tumors (OMT) to assess its usefulness in differential diagnosis and its correlation with 1p/19q status; in particular, INA expression in gliomas with isolated/partial 1p or 19q deletions was assessed. α-Internexin expression and 1p/19q codeletion were present in 92% (34/37) of codeleted tumors (p < 0.0001). By contrast, INA was found in only 20% of cases with isolated/partial 1p aberrations and 36% of cases without 1p/19q deletions; it was also foundin 63% (10/16) of cases with isolated/partial 19q aberrations. α-Internexin expression was more specific in high-grade than in low-grade gliomas (66% vs 31%). Notably, a subset of tumors (10/83) displayed a biphasic INA expression pattern that was significantly associated with proliferation rate, whereas all areas harbored the 1p/19q codeletion. Only no or weak INA expression was seen in OMTs. In summary, INA is a useful marker to differentiate OTs from astrocytic tumors and OMTs, but INA expression is not exclusively linked to OTs harboring the 1p/19q codeletion. Moreover, it can sometimes be heterogeneously distributed within tumors, which emphasizes the need for 1p/19q analysis by molecular genetic techniques for diagnosis.
- Subjects :
- Pathology
medicine.medical_specialty
α internexin
Oligodendroglioma
Statistics as Topic
Biology
Gene Expression Regulation, Enzymologic
Pathology and Forensic Medicine
Cellular and Molecular Neuroscience
Expression pattern
Intermediate Filament Proteins
Glioma
Proliferation rate
medicine
Humans
Oligodendroglial Tumor
Regulation of gene expression
Brain Neoplasms
General Medicine
medicine.disease
Neurology
Chromosomes, Human, Pair 1
Neurology (clinical)
Differential diagnosis
Chromosome Deletion
Chromosomes, Human, Pair 19
Microsatellite Repeats
Subjects
Details
- ISSN :
- 15546578
- Volume :
- 70
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of neuropathology and experimental neurology
- Accession number :
- edsair.doi.dedup.....16d0b3d597ee63ef082952cead0c3c41