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Gastrointestinal cancers in India: Treatment perspective
- Source :
- South Asian Journal of Cancer, South Asian Journal of Cancer, Vol 5, Iss 3, Pp 126-136 (2016)
- Publication Year :
- 2016
- Publisher :
- Georg Thieme Verlag KG, 2016.
-
Abstract
- GI cancer is not one cancer but is a term for the group of cancers that affect the digestive system including gastric cancer (GC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), esophageal cancer (EC), and pancreatic cancer (PC). Overall, the GI cancers are responsible for more cancers and more deaths from cancer than any other organ. 5 year survival of these cancers remains low compared to western world. Unlike the rest of the world where organ based specialities hepatobiliary, pancreatic, colorectal and esophagogastric exist , these cancers are managed in India by either a gastrointestinal surgeons, surgical oncologist, or a general surgeon with varying outcomes.The aim of this review was to collate data on GI cancers in indian continent. In colorectal cancers, data from tertiary care centres identifies the unique problem of mucinous and signet colorectal cancer. Results of rectal cancer resection in terms of technique (intersphincteric resection, extralevator aper, minimal invasive approach ) to be comparable with world literature. However long term outcome and data regarding colon cancers and nationally is needed. Gastric cancer at presentation are advanced and in surgically resected patients, there is need for a trial to compare chemoradiation vs chemotherapy alone to prevent loco regional recurrence. Data on minimal invasive gastric cancer surgery may be sparse for the same reason. Theree is a lot of data on surgical techniques and perioperatve outcomes in pancreatic cancer. There is a high volume of locally advanced gallbladder cancers with efforts on to decide whether neoadjuvant chemotherapy or neoadjuvant chemoradiotherapy is better for down staging. Considering GI cancers, a heterogeneous disease with site specific treatment options and variable outcomes, the overall data and outcomes are extremely variable. Young patients with pathology unique to the Indian subcontinent (for example, signet ring rectal cancer, GBCs) need focussed attention. Solution for such pathology needs to come from the Indian continent itself. Joint efforts to improve outcomes for GI cancer can be integrated under the national cancer grid program.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
India
Review Article
Disease
lcsh:RC254-282
Colorectal cancers
03 medical and health sciences
0302 clinical medicine
Internal medicine
Pancreatic cancer
medicine
pancreatic cancers
gastric cancers
Chemotherapy
business.industry
Cancer
Esophageal cancer
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
gallbladder cancers
Review article
030220 oncology & carcinogenesis
Hepatocellular carcinoma
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 22784306 and 2278330X
- Database :
- OpenAIRE
- Journal :
- South Asian Journal of Cancer
- Accession number :
- edsair.doi.dedup.....16cd18d37b0eb55e778e1343fa594e32