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Archive for Research in Child Health (ARCH) and Baby Gut: Study Protocol for a Remote, Prospective, Longitudinal Pregnancy and Birth Cohort to Address Microbiota Development and Child Health
- Source :
- Methods and Protocols, Vol 4, Iss 52, p 52 (2021), Methods and Protocols
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The infant gut microbiome is shaped by numerous factors such as diet and the maternal microbiota and is also associated with later atopy and obesity. The Archive for Research in Child Health and Baby Gut (ARCHBG) cohort was established in 2015 to (1) understand how the development of the infant gut microbiota is associated with atopy, obesity, and gastrointestinal disease and (2) characterize the associations of maternal pre-pregnancy BMI and infant diet with the development of the gut microbiota. Study participants for ARCHBG are convenience samples recruited through two pipelines in Lansing and Traverse City, Michigan: (1) Archive for Research in Child Health (ARCHGUT) and (2) BABYGUT. A total of (n = 51) mother–infant dyads have been enrolled to date. This prospective cohort study collects maternal pre-pregnancy fecal samples, maternal data, child fecal samples at four timepoints (one week, six months, 12 months, and 24 months), and child data up to five years of age. All samples and data are collected remotely by mail, phone, or drop-off at select locations. Of all participants enrolled, 76.5% (n = 39) of infants have a complete record of stool samples. At least 88.2% (n = 45) of fecal samples were submitted at each timepoint. ARCHBG will allow for a nuanced understanding of the temporal development of the infant gut microbiome and numerous child health outcomes.
- Subjects :
- 0301 basic medicine
Pediatrics
medicine.medical_specialty
QH301-705.5
gut microbiome
Gut flora
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Atopy
Study Protocol
03 medical and health sciences
0302 clinical medicine
Structural Biology
medicine
microbiota
030212 general & internal medicine
infancy
Biology (General)
Prospective cohort study
Feces
child development
Pregnancy
biology
human milk exposure
business.industry
cohort
medicine.disease
biology.organism_classification
Child development
Obesity
030104 developmental biology
Cohort
pregnancy
business
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 24099279
- Volume :
- 4
- Issue :
- 52
- Database :
- OpenAIRE
- Journal :
- Methods and Protocols
- Accession number :
- edsair.doi.dedup.....16c9e7a99044f98f27bb97ff6f98f855