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Recent Advances in Small Peptides of Marine Origin in Cancer Therapy
- Source :
- Marine Drugs, Marine Drugs, Vol 19, Iss 115, p 115 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. This paper highlights the anticancer linear and cyclic small peptides in marine resources and presents a review of peptides and the derivatives and their mechanisms.
- Subjects :
- Aquatic Organisms
Antineoplastic drug
Cancer therapy
Pharmaceutical Science
Antineoplastic Agents
Computational biology
Review
Biology
Peptides, Cyclic
cyclic peptide
03 medical and health sciences
0302 clinical medicine
anticancer medicine
Neoplasms
Drug Discovery
Small peptide
small peptide
medicine
Animals
Humans
marine organism
lcsh:QH301-705.5
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Cancer
medicine.disease
Cyclic peptide
lcsh:Biology (General)
chemistry
Biological species
030220 oncology & carcinogenesis
liner peptide
Peptides
Gastrointestinal function
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 19
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Marine Drugs
- Accession number :
- edsair.doi.dedup.....16b3306df29fda98afe6f85c8fd4fcd5