Back to Search
Start Over
Addition of Amlodipine or Valsartan for Improvement of Diastolic Dysfunction Associated with Hypertension
- Source :
- Journal of Cardiovascular Imaging
- Publication Year :
- 2020
- Publisher :
- Korean Society of Echocardiography, 2020.
-
Abstract
- BACKGROUND Hypertensive patients are at increased risk of diastolic dysfunction. The hypothesis of this study was that addition of amlodipine would be superior to valsartan in improving diastolic dysfunction associated with hypertension. METHODS In this randomized trial, we randomly assigned 104 controlled, hypertensive patients with diastolic dysfunction to receive either amlodipine 2.5 mg or valsartan 40 mg, in addition to antihypertensive therapy. The primary end point was the change in the ratio of early mitral inflow velocity to early mitral annular relaxation velocity (E/E') from baseline to the 6-month follow-up. Secondary end points included changes in systolic blood pressure (SBP), left ventricular (LV) mass index, and left atrial volume index. RESULTS SBP decreased significantly from baseline in both treatment groups (p < 0.001). E/E' decreased significantly from 13.0 ± 2.2 to 12.0 ± 2.7 in the amlodipine arm and from 14.4 ± 4.3 to 12.7 ± 3.7 in the valsartan arm (p < 0.01 in both groups). The change of E/E' was not significantly different between treatment groups (p = 0.25). There were also no significant between-group differences regarding the changes in SBP, LV mass index, and left atrial volume index. Two patients (3.8%) in the amlodipine group and 1 (16%) in the valsartan group had serious adverse event. CONCLUSIONS In this randomized trial involving controlled hypertensive patients, addition of amlodipine or valsartan was associated with an improvement of diastolic dysfunction, but the effects on diastolic dysfunction did not differ significantly between the treatment groups.
- Subjects :
- medicine.medical_specialty
business.industry
Diastole
law.invention
Blood pressure
Valsartan
Randomized controlled trial
law
Internal medicine
Hypertension
medicine
Clinical endpoint
Cardiology
Diastolic dysfunction
Radiology, Nuclear Medicine and imaging
Mass index
Original Article
Amlodipine
Cardiology and Cardiovascular Medicine
business
Adverse effect
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 25867296 and 25867210
- Volume :
- 28
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....167108d50f5e98aeac1bf7e4e127f042