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Quantitative Analysis of Aconitum Alkaloids in the Urine and Serum of a Male Attempting Suicide by Oral Intake of Aconite Extract
- Source :
- Journal of Analytical Toxicology. 22:336-340
- Publication Year :
- 1998
- Publisher :
- Oxford University Press (OUP), 1998.
-
Abstract
- A method for the quantitation of diesterditerpene-type Aconitum alkaloids and their hydrolysis products by gas chromatography-selected ion monitoring was applied to a clinical case study. A 45-year-old male attempted suicide by oral intake of Aconitum alkaloids, which are highly intoxicant extracts of Aconitum tubers. It was estimated that he had ingested approximately 11 mg of diesterditerpene-type alkaloids but was saved by intensive gastric irrigation. Mesaconitine, aconitine, hypaconitine, and their hydrolysis products were detected in the serum on the first day only. On the other hand, some alkaloids were still detectable in the urine even six days after intoxication. Aconitum alkaloids are biotransformed, and their hydrolysis products are excreted time-dependently to the urine. The urine was a useful material to identify the toxicants in the case of aconite intoxication.
- Subjects :
- Male
Health, Toxicology and Mutagenesis
Metabolite
Suicide, Attempted
Ranunculaceae
Urine
Toxicology
complex mixtures
Gas Chromatography-Mass Spectrometry
Analytical Chemistry
chemistry.chemical_compound
Blood serum
Oral administration
Humans
Environmental Chemistry
Aconitine
heterocyclic compounds
Aconitum
Chemical Health and Safety
Chromatography
biology
Traditional medicine
Plant Extracts
Hydrolysis
Poisoning
organic chemicals
Alkaloid
Middle Aged
biology.organism_classification
chemistry
Subjects
Details
- ISSN :
- 19452403 and 01464760
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Analytical Toxicology
- Accession number :
- edsair.doi.dedup.....166813396346a410ea5dd32ee7a3bd9f