Back to Search
Start Over
Low hemoglobin levels are associated with direct antiglobulin test positivity in patients with acute-on-chronic liver failure
- Source :
- Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 60(5)
- Publication Year :
- 2020
-
Abstract
- Multiple factors contribute to anemia in patients with Hepatitis B virus (HBV)related acute-on-chronic liver failure (ACLF); however, the mechanism is unclear. The purpose of this study was to evaluate the clinical significance of the direct antiglobulin test (DAT) in patients with HBV related ACLF.DAT was used to detect immunoglobulins and/or complement proteins on the surface of erythrocytes.We recruited 78 HBV-associated ACLF patients, 30 chronic hepatitis B(CHB)patients and 40 healthy people between October 2015 and May 2016. In HBV related ACLF patients, the hemoglobin concentration, number of erythrocytes, and hematocrit value were significantly lower, while the erythrocyte distribution width was significantly higher, compared to patients with CHB and healthy controls (HCs) (P0.001). The rates of DAT positivity in HBV related ACLF patients, CHB patients, and HCs were 62.8 %, 13.3 %, and 0%, respectively. DAT-positive ACLF patients exhibited lower Hb levels, older average age, as well as higher total bilirubin, alanine aminotransferase, and complement component 3 levels compared to DAT-negative patients.HBV related ACLF patients showed significant alterations in erythrocyte parameters, possibly reflecting disease development and severity. The high presence of erythrocyte autoantibodies suggested that immunologic clearance of erythrocytes contributed to multifactorial anemia in HBV related ACLF patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Erythrocytes
Anemia
Disease
Hematocrit
medicine.disease_cause
Gastroenterology
Hemoglobins
Hepatitis B, Chronic
Internal medicine
medicine
Humans
Clinical significance
Aged
Hepatitis B virus
biology
medicine.diagnostic_test
business.industry
Autoantibody
Acute-On-Chronic Liver Failure
Reproducibility of Results
Alanine Transaminase
Bilirubin
Hematology
Complement System Proteins
Middle Aged
medicine.disease
Coombs Test
biology.protein
Female
Hemoglobin
Antibody
business
Subjects
Details
- ISSN :
- 14730502
- Volume :
- 60
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
- Accession number :
- edsair.doi.dedup.....166734f3cbc52df13e0cda57f55a3ed5