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Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study
- Source :
- Cancer. 126:4246-4255
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background Many breast cancer survivors suffer from cognitive complaints after cancer treatment, affecting their quality of life. The objective of this pilot study was to investigate the effect of a blended‐care mindfulness‐based intervention (MBI) on chemotherapy‐related cognitive impairment and functional brain changes. Furthermore, correlations between changes in cognitive functioning and self‐reported behavioral factors were investigated. Methods Breast cancer survivors (n = 33) who reported cognitive impairment were randomly allocated to a mindfulness condition (n = 18) or a waitlist control condition (n = 15). Patients completed questionnaires on cognitive impairment, emotional distress, and fatigue; neuropsychological tests; and resting‐state functional magnetic resonance imaging before the start of MBI (time 1 [T1]), immediately after the completion of an 8‐week MBI program (T2), and 3 months postintervention (T3). Resting‐state functional connectivity was estimated in the default mode network, the dorsal and salience attention networks, and the frontoparietal network. Mixed model repeated‐measures analysis was performed to test the intervention effect. Results Patients in the mindfulness condition exhibited significantly higher connectivity between the dorsal and salience attention networks after the mindfulness intervention compared with those in the control condition. MBI participants also had reduced subjective cognitive impairment, emotional distress, and fatigue. No intervention effect was observed on neurocognitive tests. Conclusions MBI may induce functional brain changes in networks related to attention and may have a positive effect on subjective measures of cognitive impairment in breast cancer survivors. Therefore, MBI could be a suitable intervention to improve quality of life in this population and deserves further study in this context. ispartof: Cancer vol:126 issue:18 pages:4246-4255 ispartof: location:United States status: published
- Subjects :
- Adult
Male
Cancer Research
Mindfulness
Adolescent
Population
Pilot Projects
Context (language use)
Young Adult
03 medical and health sciences
0302 clinical medicine
Quality of life
Humans
Medicine
Cognitive Dysfunction
030212 general & internal medicine
Cognitive skill
education
education.field_of_study
Resting state fMRI
business.industry
Neuropsychology
Cognition
Middle Aged
Magnetic Resonance Imaging
Oncology
030220 oncology & carcinogenesis
Female
business
Clinical psychology
Subjects
Details
- ISSN :
- 10970142 and 0008543X
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi.dedup.....1662a0b188dd348474e512637399e055