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Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
- Source :
- Molecules; Volume 27; Issue 13; Pages: 3970, MOLECULES, Molecules: a journal of synthetic chemistry and natural product chemistry
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation.
- Subjects :
- Iron
BIOLOGY
Pharmaceutical Science
Apoptosis
IONP-GA
Analytical Chemistry
DELIVERY
Cell Line, Tumor
Neoplasms
Drug Discovery
Medicine and Health Sciences
Ferroptosis
Physical and Theoretical Chemistry
IONP–GA/PAA
MAGNETIC NANOPARTICLES
PAA
STABILITY
Organic Chemistry
DEATH
Biology and Life Sciences
ferroptosis
Chemistry
Chemistry (miscellaneous)
ACID
cancer cells
Nanoparticles
Molecular Medicine
Magnetic Iron Oxide Nanoparticles
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....1651b6d6c3deb7627a6384baf5f9a806