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Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines

Authors :
Roberto Fernández-Acosta
Claudia Iriarte-Mesa
Daniel Alvarez-Alminaque
Behrouz Hassannia
Bartosz Wiernicki
Alicia M. Díaz-García
Peter Vandenabeele
Tom Vanden Berghe
Gilberto L. Pardo Andreu
Source :
Molecules; Volume 27; Issue 13; Pages: 3970, MOLECULES, Molecules: a journal of synthetic chemistry and natural product chemistry
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation.

Details

ISSN :
14203049
Volume :
27
Database :
OpenAIRE
Journal :
Molecules
Accession number :
edsair.doi.dedup.....1651b6d6c3deb7627a6384baf5f9a806