Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus

The patient (nPOD 6310) was a 28-year-old female, 32 days postoperative from a cesarean delivery. Her past medical history was significant for chronic hypertension, severe preeclampsia, acute renal failure, and gestational diabetes mellitus (GDM). She was brought to the emergency department after collapsing, with total downtime of 20–30 min. On arrival, she was admitted to the intensive care unit and found to be in hypertensive crisis. Her hospital course was complicated by renal failure requiring four rounds of hemodialysis, hypertension requiring multiple agents for control, and a degree of hyperglycemia requiring insulin. Computed tomography of the head demonstrated anoxic encephalopathy with multiple infarcts within the brain. The patient was declared brain-dead and, with authorization obtained from next of kin, became an organ donor. The pancreas, along with blood, was recovered for research through the Network for Pancreatic Organ …