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Activin E enhances insulin sensitivity and thermogenesis by activating brown/beige adipocytes
- Source :
- The Journal of Veterinary Medical Science
- Publication Year :
- 2019
- Publisher :
- The Japanese Society of Veterinary Science, 2019.
-
Abstract
- Activin E, a secreted peptide encoded by the inhibin/activin βE subunit gene, is a member of the transforming growth factor-β superfamily, which is predominantly expressed in the liver. Recent reports have suggested that activin E plays a role in energy homeostasis as a hepatokine. Here, using transgenic mice overexpressing activin E under the control of the β-actin promoter, we demonstrate that activin E controls energy metabolism through brown/beige adipocytes. The glucose tolerance test and insulin tolerance test showed that the insulin sensitivity was improved in the transgenic mice. Furthermore, the mice had a high body temperature compared with wild-type mice. The transgenic brown adipose tissue and mesenteric white adipose tissue showed upregulation of uncoupling protein 1, which enables energy dissipation as heat by uncoupling oxidative phosphorylation from ATP production. Present results indicate that activin E activates energy expenditure through brown/beige adipocyte activation, suggesting that activin E has high potential for obesity therapy.
- Subjects :
- medicine.medical_specialty
endocrine system
UCP1
animal structures
040301 veterinary sciences
Transgene
Adipose Tissue, White
Mice, Transgenic
White adipose tissue
INHBE
Energy homeostasis
Body Temperature
0403 veterinary science
03 medical and health sciences
Mice
Downregulation and upregulation
Adipose Tissue, Brown
Internal medicine
Brown adipose tissue
hepatokine
Glucose Intolerance
medicine
Animals
Adipocytes, Beige
Uncoupling Protein 1
030304 developmental biology
0303 health sciences
General Veterinary
Full Paper
Chemistry
Insulin tolerance test
Thermogenesis
04 agricultural and veterinary sciences
Thermogenin
Actins
Activins
Mice, Inbred C57BL
medicine.anatomical_structure
Endocrinology
Adipocytes, Brown
embryonic structures
Anatomy
Insulin Resistance
Energy Metabolism
hormones, hormone substitutes, and hormone antagonists
browning/beiging
Subjects
Details
- Language :
- English
- ISSN :
- 13477439 and 09167250
- Volume :
- 81
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....163aab913f257d46b09f33341dd58eef