Back to Search Start Over

Effects of short-term atorvastatin use in patients with calcium stones: A randomized placebo-controlled clinical trial

Authors :
Abbas Basiri
Fatemeh Taheri
Maryam Taheri
Alireza Khoshdel
Sanaz Tavasoli
Fariba Samadian
Source :
Investigative and Clinical Urology, Investigative and Clinical Urology, Vol 60, Iss 6, Pp 472-479 (2019)
Publication Year :
2019

Abstract

Purpose: A few experimental and observational studies have reported that atorvastatin prevents calcium oxalate stone formation. Our study is the first to investigate the effect of atorvastatin on 24-hour urinary metabolites, urinary malondialdehyde (U-MDA) (an oxidative stress marker) and urinary neutrophil gelatinase-associated lipocalin (U-NGAL) (a renal tubular injury marker) in patients with calcium stones and hyperoxaluria. Materials and Methods: This randomized, double-blind, placebo-controlled, parallel-group clinical trial included 32 adults with recurrent calcium stone formation and hyperoxaluria. All participants received a 3-month course of either atorvastatin (20 mg/d) or placebo of an identical shape. Both groups received the usual nutritional care based on the European Association of Urology guidelines. Results: Twenty-eight participants completed the study. Serum levels of total and low-density lipoprotein cholesterol decreased in the atorvastatin group, and these changes were significantly different between groups (p

Details

ISSN :
2466054X
Volume :
60
Issue :
6
Database :
OpenAIRE
Journal :
Investigative and clinical urology
Accession number :
edsair.doi.dedup.....163a58cea9ad9f9a7a155d25a8cbb4c8