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Effects of short-term atorvastatin use in patients with calcium stones: A randomized placebo-controlled clinical trial
- Source :
- Investigative and Clinical Urology, Investigative and Clinical Urology, Vol 60, Iss 6, Pp 472-479 (2019)
- Publication Year :
- 2019
-
Abstract
- Purpose: A few experimental and observational studies have reported that atorvastatin prevents calcium oxalate stone formation. Our study is the first to investigate the effect of atorvastatin on 24-hour urinary metabolites, urinary malondialdehyde (U-MDA) (an oxidative stress marker) and urinary neutrophil gelatinase-associated lipocalin (U-NGAL) (a renal tubular injury marker) in patients with calcium stones and hyperoxaluria. Materials and Methods: This randomized, double-blind, placebo-controlled, parallel-group clinical trial included 32 adults with recurrent calcium stone formation and hyperoxaluria. All participants received a 3-month course of either atorvastatin (20 mg/d) or placebo of an identical shape. Both groups received the usual nutritional care based on the European Association of Urology guidelines. Results: Twenty-eight participants completed the study. Serum levels of total and low-density lipoprotein cholesterol decreased in the atorvastatin group, and these changes were significantly different between groups (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Urology
Urinary system
Atorvastatin
030232 urology & nephrology
Calcium oxalate
chemistry.chemical_element
Calcium
Placebo
lcsh:RC870-923
Hydroxymethylglutaryl-CoA reductase inhibitors
03 medical and health sciences
chemistry.chemical_compound
Kidney Calculi
0302 clinical medicine
Double-Blind Method
Lipocalin-2
Urolithiasis
Malondialdehyde
Medicine
Humans
Creatinine
business.industry
Middle Aged
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Treatment Outcome
chemistry
Oxidative stress
030220 oncology & carcinogenesis
Endourology/Urolithiasis
Kidney stones
Female
Original Article
business
medicine.drug
Subjects
Details
- ISSN :
- 2466054X
- Volume :
- 60
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Investigative and clinical urology
- Accession number :
- edsair.doi.dedup.....163a58cea9ad9f9a7a155d25a8cbb4c8